Research Description
To decipher underlying mechanisms in early life influencing the development of asthma, we focus on environmental factors like active tobacco cigarette consumption and vaping. We hypothesize that parental smoking behaviors during their own sexual maturation impacts epigenetic modulation in their oocytes and spermatogonia. Utilizing a mouse model, we investigate how smoking of the father during his own puberty increases the asthma susceptibility of his future offspring. With our fly model (Drosophila melanogaster), we explore the consequences of maternal e-cigarette consumption before conception on their offsprings’ development and asthma risk genes. In COPD, cigarette smoking is one of the main causes and many patients suffer from comorbid obesity. As in current science, the obesity is rarely explored in COPD disease models, we established a murine COPD model with comorbid obesity and bacterial airway infestion to investigate the higher exacerbation severity observed in those patients. All together, we aim to prevent disease development and lung function decline as well as mitigate disease progression.
Funding Logos
Project leader
-
Prof. Dr. Susanne Krauss-Etschmann
Principal Investigator
Team
-
Dr. Barbara Hammer
Post-Doc -
Dr. Gabriele Schramm
Post-Doc -
Dr. Leizhi Shi
Post-Doc -
Daniel Meißner
PhD-student -
Sheikh Anika Rahman
PhD-student -
Xijie Zhang
PhD-student -
Janin Braun
Lab technician -
Nina Budriks
Lab technician -
Beate Höschler
Lab technician -
Patricia Prilla
Lab technician -
Handan Müftüoglu
Assistance
Publications
-
Cell reports. Medicine
·
CYP19A1 mediates severe SARS-CoV-2 disease outcome in males
S. Stanelle-Bertram, S. Beck, N. K. Mounogou, B.Schaumburg, F. Stoll, A. Al Jawazneh, Z. Schmal, T. Bai, M. Zickler, G. Beythien, K. Becker, M. de la Roi, F. Heinrich, C. Schulz, M. Sauter, S.Krasemann, P. Lange, A. Heinemann, D. van Riel, L. Leijten, L. Bauer, Th. P.P. van den Bosch, B. Lopuhaä, T. Busche, D.Wibberg, D. Schaudien, T. Goldmann, A. Lüttjohann, J. Ruschinski, H. Jania, Z. Müller, V. P. dos Reis, V. Krupp-Buzimkic, M. Wolff, C. Fallerini, M. Baldassarri, S. Furini, K. Norwood, C. Käufer, N. Schützenmeister, M. von Köckritz-Blickwede, M. Schroeder, D. Jarczak, A. Nierhaus, T. Welte, S.Kluge, A. C. McHardy, F. Sommer, J. Kalinowski, S. Krauss-Etschmann, F. Richter, J. von der Thüsen, W. Baumgärtner, K.Klingel, B. Ondruschka, GEN-COVID Multicenter Study
-
European Respiratory Journal
·
Antiviral CD8+ T-cell immune responses are impaired by cigarette smoke and in COPD
Chen, J, Wang, X, Schmalen, A, Haines, S, Wolff, M, Ma, H, Zhang, H, Stoleriu, MG, Nowak, J, Nakayama, M, Bueno, M, Brands, J, Mora, AL, Lee, JS, Krauss-Etschmann, S, Dmitrieva, A, Frankenberger, M, Hofer, TP, Noessner, E, Moosmann, A, Behr, J, Milger, K, Deeg, CA, Staab-Weijnitz, CA, Hauck, SM, Adler, H, Goldmann, T, Gaede, KI, Behrends, J, Kammerl, IE & Meiners, S
-
Immun Inflamm Dis
·
Oral application of vancomycin alters murine lung microbiome and pulmonary immune responses
S. Pfeiffer, G. Jatzlauk, J.V. Lund, E. Boateng E, D. Kovacevic, M. Hylkema, S. Bartel, M. Schloter, S. Krauss-Etschmann (corresponding author)
-
Nature Communications
·
Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life
Jacobsen H, Walendy-Gnirß K, Tekin-Bubenheim N, Kouassi NM, Ben-Batalla I, Berenbrok N, Wolff M, Dos Reis VP, Zickler M, Scholl L, Gries A, Jania H, Kloetgen A, Düsedau A, Pilnitz-Stolze G, Jeridi A, Yildirim AÖ, Fuchs H, Gailus-Durner V, Stoeger C, de Angelis MH, Manuylova T, Klingel K, Culley FJ, Behrends J, Loges S, Schneider B, Krauss-Etschmann S, Openshaw P, Gabriel G
-
Front Med (Lausanne)
·
Cigarette Smoke Affects Dendritic Cell Populations, Epithelial Barrier Function, and the Immune Response to Viral Infection With H1N1
O. Danov, M. Wolff, S. Bartel, S. Böhlen, H. Obernolte, S. Wronski , D. Jonigk, B. Hammer, D. Kovacevic, S. Reuter, S. Krauss-Etschmann*, K. Sewald