Research Description
The Intestinal Microbiology Working Group investigates the human gut microbiome in the context of health, disease and human evolution. The aim is to use modern genomic and functional methods to systematically investigate the structural and functional diversity of the gut microbiome, as well as its role in chronic diseases, and to harness this knowledge for therapeutic purposes.
A particular focus is on the representative mapping of the global microbial diversity of the human gut, with a view to overcoming existing biases in microbiome research. Working closely with international partners, particularly from low- and middle-income countries, the research group utilises biobanks from the international Global Microbiome Conservancy initiative as well as clinical biobanks at the University of Kiel. Using in vitro, ex vivo and bioinformatic analyses, the group identifies microbial functions associated with lifestyle factors as well as health and disease states.
Main Focus
Genomic and functional characterisation of the gut microbiome
We are investigating the genetic and functional diversity of gut microorganisms in order to gain a better understanding of their role in health and disease.
Global diversity of the human gut microbiome
Through international collaborations and the use of biobanks, we are investigating the microbial diversity of the human gut in different populations around the world.
Microbial functions and the therapeutic potential of the microbiome
We identify microbial functions that are associated with lifestyle, health conditions and chronic diseases, and which have therapeutic potential.
Funding Logos
Project leader
-
Prof. Dr. Mathilde Poyet
Principal Investigator(0431) 500-15158
Team
-
Lars Bädeker
Project coordination -
Annika Gröning
Project coordination(0431) 500-15158
-
Alexandra Deutsch
PhD-student -
Ana Schaan
Post-Doc -
Li Pan
PhD-student -
Laura Catharina Mews
PhD-student -
John Costa
Lab technician -
Andre Geisler
PhD-student -
Hannah Jebens
Lab manager, Lab technician(0431) 500-15148
-
Emmanuel K. Quaye
PhD-student -
Lucas Moitinho e Silva
Post-Doc -
Malte Rühlemann
Post-Doc -
Alvaro Quevedo Olmos
PhD-student -
Fanny Mazzamurro
Post-Doc -
Hina Ayub
PhD-student -
Johanna Saalfrank
PhD-student -
Katrin Borof
PhD-student -
Handan Müftüoglu
Assistance
Publications
-
Journal of Chron’s and Colitis
·
Mapping adaptive immune responses toward fungal antigens in inflammatory bowel disease using T cell repertoire sequencing and phage-immunoprecipitation sequencing
Mahdy A, ElAbd H, Prinzensteiner M, Jebens H, Sivickis K, Bacher P, Vogl T, Poyet M, Franke A
-
Gut Microbes
·
Genome-scale metabolic models predict diet- and lifestyle-driven shifts of ecological interactions in the gut microbiome
Marinos G, Moors KA, Schlicht K, Rühlemann M, Waschina S, Lieb W, Franke A, Laudes M, Groussin M, Poyet M, Kaleta C, Kadibalban AS
-
Sustainable Microbiology
·
Policy Briefing: from access to use—untangling the international legal frameworks that govern microbial resources
Faggionato D, Muñoz-García M, Kostic T, Ferrari ML, Vonaesch P, Poyet M, Portier P, Ryan MJ, Djeddour D, Stumptner C, Varese GC, Zuzuarregui A, Groussin M, Schloter M, Finn RD, Haas AS, Probert I, Verkley G, Overmann J, Scholz AH
-
Sustainable Microbiology
·
Policy in Practice: How to do the Nagoya Protocol: common misconceptions, challenges and best practices for access and benefit-sharing compliance
Faggionato D , Muñoz-García M, Kostic T, Ferrari ML, Vonaesch P, Poyet M, Portier P, Ryan MJ, Djeddour D, Stumptner C , Varese GC, Zuzuarregui A, Groussin M, Schloter M, Finn RD, Haas AS, Probert I, Verkley G, Overmann J, Scholz AH
-
Nature Communications
·
Phosphorothioate DNA modification byBREX type 4 systems in the human gutmicrobiome
Yuan Y, DeMott MS, Byrne SR, Flores K, Poyet M, Groussin M, Berdy B, Bahunde JR, Girard C, Lehtimäki J, Mabulla AZP, Mwikarago IE, Nartey YA, Nguyen LTT, Onyekwere CA, Roberts LR, Shapiro BJ, Vatanen T, Comstock LE, Alm E, Dedon P
-
preprint
·
Convergent genomic responses of human gut bacteria to variations in industrialization
Rühlemann M, Szánthó LL, Waschina S, Moitinho-Silva L, Mews LK, Camarena JF, Jebens H, Costa J, Juimo V, Fezeu A, Agyei A, Afihene MY, Asibey SO, Awuku YA, Duah A, Nartey YA, Ibrahim F, Lim YAL, Pin TM, Onyekwere C, Rusine J, Mwikarago IE, Baines J, Franke A, Szöllősi GJ, Xavier R, Alm EJ, Groussin M, Poyet M
-
preprint
·
Industrialization drives convergent microbial and physiological shifts in the human metaorganism
Poyet M, Rühlemann M, Schaan AP, Ma Y, Moitinho-Silva L, Wacker EM, Jebens H, Patel L, Nguyen LTT, Zimmer A, Plichta D, McDonald D, Stevens C, Agyei A, Afihene MY, Asibey SO, Awuku YA, Badiane AS, Ching LS, Corzett C, Deme A, Dominguez-Rodrigo M, Duah A, Fezeu A, Froment A, Gibbons S, Girard C, Hooker J, Ibrahim F, Iqaluk D, Juimo V, Kettunen P, Lafosse S, Lango-Yaya E, Lehtimäki J, Lim YAL, Mabulla A, Mahachai V, Mohamed RS, Moniz K, Mwikarago IE, Nartey YA, Ndiaye D, Noel M, Onyekwere C, Pin TM, Plymoth A, Roberts L, Ruokolainen L, Rusine J, Segurel L, Shapiro BJ, Sigwazi S, Sistiaga A, Valles K, Vatanen T, Vilaichone R, Rosenstiel P, Baines J, Franke A, Ellinghaus D, Knight R, Daly M, Xavier RJ, Alm EJ, Groussin M
-
Scientific Reports
·
Gut microbiota profiles of peninsular Malaysian populations are associated with urbanization and lifestyle
Jamaluddin NF, Brovkina O, Rashid NN, Al-Maleki AR, Lim YAL, Tan MP, Lee SC, Duvallet C, Corzett CH, Alm E, Groussin M, Poyet M, Ibrahim F
-
mSystems
·
Temporal dynamics of gut microbiomes in non-industrialized urban Amazonia
Schaan A, Vidal A, Zhang A, Poyet M, Alm E, Groussin M, Ribeiro-dos-Santos Â
-
Nature Communications
·
Functional host-specific adaptation of the intestinal microbiome in hominids
Rühlemann MC, Groussin M, Bang C, Gogarten JF, Hermes BM, Waschina S, Poyet M, Ulrich M, Akoua-Koffi C, Deschner T, Muyembe-Tamfum JJ, Robbins MM, Surbeck M, Wittig RM, Zuberbühler K, Baines JF, Leendertz FH, Franke A